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Comparative genomic hybridization: A new tool for reproductive pathology
- Article from:
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Archives of Pathology & Laboratory Medicine
- Article date:
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January 1, 2001
- Author:
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Copyright informationCopyright College of American Pathologists Jan 2001. Provided by ProQuest LLC. (Hide copyright information)
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* Objective.-To demonstrate the effectiveness of comparative genomic hybridization (CGH) for analysis of reproductive pathology specimens in clinical cytogenetics laboratories.
Design.-A total of 856 CGH analyses were performed on various placental and fetal tissues derived from 368 specimens of spontaneous abortions and on placentas from 219 pregnancies with live-born infants. The live-born infants were clinically evaluated as normally developed, with either a normal birth weight or with intrauterine growth restriction; some live-born infants had an abnormal prenatal triple screen with normal cytogenetic results on amniotic fluid cell cultures.
Results.-Comparative genomic hybridization ...