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Article: Insulin resistance and pre-eclampsia: a role for tumor necrosis factor-[alpha]?
- Article from:
- Gynecological Endocrinology
- Article date:
- March 1, 2004
- Author:
CopyrightCopyright CRC Press Mar 2004. Provided by ProQuest LLC. (Hide copyright information)
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Key words: INSULIN, INSULIN RESISTANCE, INSULIN RESISTANCE INDEX, TNF-[alpha], PRE-ECLAMPSIA
ABSTRACT
Insulin resistance occurs in pre-eclampsia, but the cause is unknown. Furthermore, it is uncertain whether women destined to develop pre-eclampsia have a pre-existing insulin resistance or whether it is acquired with the development of the disease. We carried out this study to test the hypotheses that the increase in insulin resistance associated with pre-eclampsia is related to higher levels of tumor necrosis factor (TNF)-[alpha], and that the increase in insulin resistance precedes the clinical onset of the disease. Fasting plasma samples were obtained from ten women who subsequently ...