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High glycemic index starch promotes hypersecretion of insulin and higher body fat in rats without affecting insulin sensitivity
- Article from:
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The Journal of Nutrition
- Article date:
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January 1, 2001
- Author:
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Copyright informationCopyright American Institute of Nutrition Jan 2001. Provided by ProQuest LLC. (Hide copyright information)
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High Glycemic Index Starch Promotes Hypersecretion of Insulin and Higher Body Fat in Rats without Affecting Insulin Sensitivity1
ABSTRACT In rats, prolonged feeding of high glycemic index (GI) starch results in basal hyperinsulinemia and an elevated insulin response to an intravenous glucose tolerance test (IVGTT). The aim of this study was to assess hepatic and peripheral insulin resistance (IR) using euglycemic hyperinsulinemic clamps. Insulin sensitivity, epididymal fat deposition and fasting leptin concentrations were compared in rats fed isocalorically a low or high GI diet for 7 wk (45% carbohydrate, 35% fat and 20% protein as energy) or a high fat diet (20% carbohydrate, 59% fat and ...
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