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Article: 17-Beta-estradiol affects brain protein synthesis rate in ovariectomized female rats
- Article from:
- The Journal of Nutrition
- Article date:
- January 1, 2001
- Author:
CopyrightCopyright American Institute of Nutrition Jan 2001. Provided by ProQuest LLC. (Hide copyright information)
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17-beta-Estradiol Affects Brain Protein Synthesis Rate in Ovariectomized Female Rats1
ABSTRACT The purpose of this study was to determine whether 17-beta-estradiol affects the rate of brain protein synthesis in ovariectomized female rats. Experiments were conducted on three groups of 12-wk-old female rats: group 1 were ovariectomized to reduce the level of plasma estradiol, group 2 were ovariectomized and treated with estradiol and group 3 were sham-operated controls. The fractional rates of protein synthesis in brain of ovariectomized rats treated with estradiol were significantly greater than that in ovariectomized rats without estradiol treatment. In the cerebral cortex and cerebellum, ...