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Article: Abnormal Motor Function Persists Following Recovery from Perinatal Copper Deficiency in Rats1,2
- Article from:
- The Journal of Nutrition
- Article date:
- August 1, 2004
- Author:
CopyrightCopyright American Institute of Nutrition Aug 2004. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT
What are the biochemical and behavioral consequences of perinatal copper deficiency? Pregnant Holtzman rats were fed a modified AIN-76A diet low in copper (0.34 mg Cu/kg and 42 mg Fe/kg) starting on gestation d 7. Seven rats received copper in their drinking water (20 mg Cu/L) (+Cu) and 7 drank deionized water (-Cu). Treatments did not affect litter size or pregnancy outcome. Compared with +Cu dams and a sample of +Cu male weanling [postnatal day (P)21] offspring, -Cu rats exhibited signs consistent with copper deficiency. P21 males were switched to a nonpurified copper-adequate diet and sampled biochemically after 3 mo and behaviorally after 3 and 6 mo of repletion (CuR). Compared ...
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