Article: Rapid Weight Loss with a High-Protein Low-Energy Diet Allows the Recovery of Ideal Body Composition and Insulin Sensitivity in Obese Dogs1,2

EXPANDED ABSTRACT

KEY WORDS: * dog * obese * weight loss * insulin * sensitivity * diet

Obesity and overweight are very common in dogs of all Western countries (1), increasing the risk of several different diseases such as cancers (2,3), osteoarticular disorders, or diabetes (4). Some studies of obesity in dogs also showed that insulin resistance (IR)4 is a prominent feature (5,6) that could result from changes in the somatotropic axis' activity. Receptors that bind insulin and insulin-like growth factor 1 (IGF-1) show immunological, structural (7), and functional analogies (8), which could explain that IGF-1 has an insulin-like activity, and participates in IR. Adipose tissue expresses ...

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