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Technical Note: Vaginal Absorption of 1,25(OH)^sub 2^D^sub 3^ in Cattle
- Article from:
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Journal of Dairy Science
- Article date:
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August 1, 2004
- Author:
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Copyright informationCopyright American Dairy Science Association Aug 2004. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT
Although exogenous 1,25-dihydroxyvitamin D^sub 3^ [1,25(OH)^sub 2^D^sub 3^] administered via intravenous, intramuscular, and oral routes has been tested for efficacy in preventing parturient hypocalcemia in dairy cows, there are few reports concerning intravaginal administration. For this study, 1,25(OH)^sub 2^D^sub 3^ was administered via the bovine vaginal lumen, and subsequent changes in blood chemistry, including levels of 1,25(OH)^sub 2^D^sub 3^ and several minerals, were measured to confirm vaginal absorption. Each of 5 heifers received a single intravaginal dose of 1 µg of 1,25(OH)^sub 2^D^sub 3^/kg body weight; a single control heifer received the ethanol carrier alone. In ...
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