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Oral vitamin C reduces the injury to skeletal muscle caused by compartment syndrome
- Article from:
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Journal of Bone and Joint Surgery
- Article date:
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August 1, 2004
- Author:
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Copyright informationCopyright British Editorial Society of Bone & Joint Surgery Aug 2004. Provided by ProQuest LLC. (Hide copyright information)
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Compartment syndrome is a unique form of ischaemia of skeletal muscle which occurs despite patency of the large vessels. Decompression allows the influx of activated leucocytes which cause further injury. Vitamin C is a powerful antioxidant which concentrates preferentially in leucocytes and attenuates reperfusion-induced muscle injury. We have evaluated the use of pretreatment with oral vitamin C in the prevention of injury caused by compartment syndrome in a rat cremasteric muscle model.
Acute and delayed effects of pretreatment with vitamin C were assessed at one and 24 hours after decompression of compartment syndrome. Muscle function was assessed electrophysiologically. Vascular, ...
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