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Article: Celiac Disease Serology and Irritable Bowel Syndrome: Does the Relationship Merit Further Evaluation?/In reply
- Article from:
- Mayo Clinic Proceedings
- Article date:
- September 1, 2004
- Author:
CopyrightCopyright Mayo Foundation for Medical Education and Research Sep 2004. Provided by ProQuest LLC. (Hide copyright information)
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To the Editor. We read with interest the study by Locke et al1 in the April 2004 issue of Mayo Clinic Proceedings on the prevalence of celiac disease serology in individuals with well-categorized irritable bowel syndrome (IBS) and dyspepsia in a primary care setting. The authors observed that the prevalence of tissue transglutaminase (TTg) was 4% (2/50), but because these individuals were endomysial antibody-negative, they did not undergo duodenal biopsy. The authors concluded that celiac disease does not explain the IBS symptoms in the vast majority of patients in a US primary care population. We were surprised by this conclusion for several reasons.
Endomysial antibody-negative celiac ...