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Article: Immunomodulatory effects of aged garlic extract
- Article from:
- The Journal of Nutrition
- Article date:
- March 1, 2001
- Author:
CopyrightCopyright American Institute of Nutrition Mar 2001. Provided by ProQuest LLC. (Hide copyright information)
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Immunomodulatory Effects of Aged Garlic Extract'
ABSTRACT Using various kinds of models, we examined the effects of aged garlic extract (AGE) on immune functions. In the immunoglobulin (Ig)E-mediated allergic mouse model, AGE significantly decreased the antigenspecific ear swelling induced by picryl chloride ointment to the ear and intravenous administration of antitrinitrophenyl antibody. In the transplanted carcinoma cell model, AGE significantly inhibited the growth of Sarcoma-180 (allogenic) and LL/2lung carcinoma (syngenic) cells transplanted into mice. Concomitantly, increases in natural killer (NK) and killer activities of spleen cells were observed in Sarcoma-180-bearing mice ...