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Article: Alcohol, One-Carbon Metabolism, and Colorectal Cancer: Recent Insights from Molecular Studies1
- Article from:
- The Journal of Nutrition
- Article date:
- September 1, 2004
- Author:
CopyrightCopyright American Institute of Nutrition Sep 2004. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT
A growing body of evidence implicates alcohol intake as a risk factor for colorectal cancer. Until recently, most of the data were based on epidemiologic data that examined alcohol intake in relation to risk of colorectal neoplasia, but the evidence has now been broadened by recent molecular studies on mechanisms. In particular, a number of observations strongly support a role for alcohol acting through disruptions in one-carbon metabolism. Excessive alcohol intake is a fairly consistent risk factor for colorectal neoplasia in most studies, and studies show much higher risks of colorectal neoplasia in those with high alcohol and low folate than with high alcohol or low folate ...
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... ... prognosis in patients with colorectal cancer (CRC), and lymph node status ... include fat stretching,[14] alcohol treatment,[10] xylene ... modified Lillie acetic acid--alcohol--formalin fixative (Table ... reagents in the following order: alcohol, distilled water, formaldehyde ...
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