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Article: Circulating Corticotropin-Releasing Hormone mRNA in Maternal Plasma: Relationship with Gestational Age and Severity of Preeclampsia
- Article from:
- Clinical Chemistry
- Article date:
- October 1, 2004
- Author:
CopyrightCopyright American Association for Clinical Chemistry Oct 2004. Provided by ProQuest LLC. (Hide copyright information)
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Higher concentrations of circulating nucleic acids (DNA and RNA) in maternal plasma/serum have been reported in pregnancies complicated by preeclampsia (PE) compared with controls matched for gestational age (1-5). Fetal and total DNA concentrations were also demonstrated to be directly correlated to both gestational age and to the severity of PE (6). Again, both hypertension and proteinuria (the two main symptoms for PE classification) are independently associated with an increase in circulating fetal DNA (6). Most studies, however, have had to rely on Y-chromosome loci, which can be used as fetus-specific markers for male fetuses. For this reason, the identification in maternal plasma of ...