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Article: A Model of Voltage Gating Developed Using the KvAP Channel Crystal Structure
- Article from:
- Biophysical Journal
- Article date:
- October 1, 2004
- Author:
CopyrightCopyright Biophysical Society Oct 2004. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT
Having inspected the crystal structure of the complete KvAP channel protein, we suspect that the voltage-sensing domain is too distorted to provide reliable information about its native tertiary structure or its interactions with the central pore-forming domain. On the other hand, a second crystal structure of the isolated voltage-sensing domain may well correspond to a native open conformation. We also observe that the paddle model of gating developed from these two structures is inconsistent with many experimental results, and suspect it to be energetically unrealistic. Here we show that the isolated voltage-sensing domain crystal structure can be docked onto the pore domain ...
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