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Article: ^sup 18^F-FDG Kinetics in Locally Advanced Breast Cancer: Correlation with Tumor Blood Flow and Changes in Response to Neoadjuvant Chemotherapy
- Article from:
- The Journal of Nuclear Medicine
- Article date:
- November 1, 2004
- Author:
CopyrightCopyright Society of Nuclear Medicine Nov 2004. Provided by ProQuest LLC. (Hide copyright information)
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The aim of this study was to characterize the biologic response of locally advanced breast cancer (LABC) to chemotherapy using ^sup 15^O-water-derived blood flow measurements and ^sup 18^F-FDG-derived glucose metabolism rate parameters. Methods: Thirty-five LABC patients underwent PET with ^sup 15^O-water and ^sup 18^F-FDG before neoadjuvant chemotherapy and 2 mo after the initiation of treatment. Kinetic analysis for ^sup 15^O-water was performed using a single tissue compartment model to calculate blood flow; a 2-tissue compartment model was used to estimate ^sup 18^F-FDG rate parameters K^sub 1^, K^sub 2^, K^sub 3^, and the flux constant, K^sub i^. Correlations and ratios between blood ...