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Article: Combined selenium and vitamin E deficiency causes fatal myopathy in Guinea pigs
- Article from:
- The Journal of Nutrition
- Article date:
- June 1, 2001
- Author:
CopyrightCopyright American Institute of Nutrition Jun 2001. Provided by ProQuest LLC. (Hide copyright information)
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Nutrient Interactions and Toxicity
Combined Selenium and Vitamin E Deficiency Causes Fatal Myopathy in Guinea Pigs1
ABSTRACT Selenium and vitamin E deficiencies were studied as part of an evaluation of oxidant defenses in guinea pigs. Male guinea pigs (100-120 g) were fed a control diet (C) or the diet without selenium (0 Se), without vitamin E (0 E), or without either selenium or vitamin E (0 Se-0 E). Between d 30 and 35, 7 of 13 guinea pigs fed the 0 Se-0 E diet were euthanized because of severe weakness of their extremities. No guinea pigs in the other diet groups developed weakness. Guinea pigs from each group were killed on d 37. Selenium deficiency and vitamin E deficiency were ...