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Article: Role of interleukin-1(beta) in a murine model of otitis media with effusion
- Article from:
- The Annals of Otology, Rhinology & Laryngology
- Article date:
- June 1, 2001
- Author:
CopyrightCopyright Annals Publishing Company Jun 2001. Provided by ProQuest LLC. (Hide copyright information)
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To clarify the role of interleukin-1beta (IL-1beta) in the pathogenesis of otitis media with effusion (OME), we developed and investigated a murine model of this disease. Specific pathogen-free male BALB/c mice received intratympanic injections of 20 (mu)g of endotoxin derived from nontypeable Haemophilus influenzae. Three days after injection, middle ear effusions were observed through the eardrum. Similar pathological changes were observed after inoculation with 100 ng of recombinant IL-1beta. Anti-IL-I receptor antibodies inhibited the pathological changes induced by the endotoxin. In situ hybridization showed expression of IL- 1beta messenger RNA in the epithelium of the middle ear ...
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