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Use of Biomarkers of Oxidative Stress in Research Studies1,2
- Article from:
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The Journal of Nutrition
- Article date:
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November 1, 2004
- Author:
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Copyright informationCopyright American Institute of Nutrition Nov 2004. Provided by ProQuest LLC. (Hide copyright information)
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EXPANDED ABSTRACT
KEY WORDS: * biomarkers * oxidative stress * antioxidants
In research studies, biomarkers can be employed to reflect environmental prooxidant exposures and dietary antioxidant intake or to serve as a surrogate measure of a disease process (1,2). To be truly useful, the biomarker must have some degree of predictive validity, but full substantiation of this relation still is lacking (3-5). A number of challenges must be overcome to obtain not only a better understanding of the contributions of reactive species to carcinogenesis but a rational application of biomarkers of oxidative stress to observational studies and clinical trials of antioxidants and cancer (6). ...
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