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Article: Seizure Prophylaxis in Patients With Brain Tumors: A Meta-analysis

Article from:
Mayo Clinic Proceedings
Article date:
December 1, 2004
Author:
Copyright

OBJECTIVE: To assess whether antiepileptic drugs (AEDs) should be prescribed to patients with brain tumors who have no history of seizures.

METHODS: We performed a meta-analysis of randomized controlled trials (1966-2004) that evaluated the efficacy of AED prophylaxis vs no treatment or placebo to prevent seizures in patients with brain tumors who had no history of epilepsy. Summary odds ratios (ORs) were calculated using a random-effects model. Three subanalyses were performed to assess pooled ORs of seizures in patients with primary glial tumors, cerebral metastases, and meningiomas.

RESULTS: Of 474 articles found in the initial search, 17 were identified as primary studies. Five trials ...

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