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Article: (n-3) Fatty Acids and Cancer Therapy1
- Article from:
- The Journal of Nutrition
- Article date:
- December 1, 2004
- Author:
CopyrightCopyright American Institute of Nutrition Dec 2004. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT
Supplementing the diet of tumor-bearing mice or rats with oils containing (n-3) (omega-3) or with purified (n-3) fatty acids has slowed the growth of various types of cancers, including lung, colon, mammary, and prostate. The efficacy of cancer chemotherapy drugs such as doxorubicin, epirubicin, CPT-11, 5-fluorouracil, and tamoxifen, and of radiation therapy has been improved when the diet included (n-3) fatty acids. Some potential mechanisms for the activity of (n-3) fatty acids against cancer include modulation of eicosanoid production and inflammation, angiogenesis, proliferation, susceptibility for apoptosis, and estrogen signaling. In humans, (n-3) fatty acids have also been ...