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Article: ^sup 99m^Tc-N-DBODC5, a New Myocardial Perfusion Imaging Agent with Rapid Liver Clearance: Comparison with ^sup 99m^Tc-Sestamibi and ^sup 99m^Tc-Tetrofosmin in Rats
- Article from:
- The Journal of Nuclear Medicine
- Article date:
- December 1, 2004
- Author:
CopyrightCopyright Society of Nuclear Medicine Dec 2004. Provided by ProQuest LLC. (Hide copyright information)
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^sup 99m^Tc-[bis (dimethoxypropylphosphinoethyl)-ethoxyethylamine (PNP5)]-[bis (N-ethoxyethyl)-dithiocarbamato (DBODC)] nitride (N-PNP5-DBODC or N-DBODC5) is a new monocationic myocardial perfusion tracer. We sought to compare the myocardial uptake and clearance kinetics and organ biodistribution of ^sup 99m^Tc-N-DBODC5 with ^sup 99m^Tc-sestamibi and ^sup 99m^Tc-tetrofosmin. Methods: Seventy-five anesthetized Sprague-Dawley rats were injected intravenously with 22.2-29.6 MBq ^sup 99m^Tc-N-DBODC5 (n = 25), ^sup 99m^Tc-sestamibi (n = 25), or ^sup 99m^Tc-tetrofosmin (n = 25). Rats were euthanized at either 2, 10, 20, 30, or 60 min after injection and γ-well counting was performed on ...