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Article: EFFECTS OF CETIRIZINE ON SUBSTANCE P RELEASE IN PATIENTS WITH PERENNIAL ALLERGIC RHINITIS
- Article from:
- The Annals of Otology, Rhinology & Laryngology
- Article date:
- December 1, 2004
- Author:
CopyrightCopyright Annals Publishing Company Dec 2004. Provided by ProQuest LLC. (Hide copyright information)
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To evaluate the effect of cetirizine hydrochloride on substance P release in allergic rhinitis, we performed a single-blind placebo-controlled study of 14 patients with perennial allergic rhinitis (7 treated with cetirizine and 7 with placebo). After an initial nasal allergen challenge with lavages, the subjects received treatment with placebo or cetirizine hydrochloride (10 mg by mouth daily) for 1 week, followed by the second nasal allergen challenge with lavages. The levels of albumin, histamine, and substance P in nasal lavages before and after allergen challenge were quantified by enzyme-linked immunosorbent assay. Pretreatment of subjects with cetirizine reduced the level of substance ...