Article: The Influence of Gender and Age on Sleep Macroarchitecture in Healthy and Depressed Children and Adolescents

Introduction: Sleep macroarchitecture in adults with depression is heavily influenced by gender. It is not known whether these gender-dependent sleep macroarchitectural disturbances in MDD appear early in development. The primary aim was to evaluate the influence of gender and age on differences in sleep macroarchitecture in healthy and depressed children and adolescents.

Methods: Participating in the study were 128 children and adolescents, ages 8-18 years of age. Seventy-five (39 F, 36 M) symptomatic depressed outpatients were compared to 53 normal controls (28 F, 25 M) matched for age. All of the outpatients met DSM-IV criteria for nonpsychotic depression and were unmedicated at the time ...

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