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Article: Plasma F^sub 2^-Isoprostanes and Coronary Artery Calcification: The CARDIA Study
- Article from:
- Clinical Chemistry
- Article date:
- January 1, 2005
- Author:
CopyrightCopyright American Association for Clinical Chemistry Jan 2005. Provided by ProQuest LLC. (Hide copyright information)
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Background: Oxidation of lipids in lipoproteins and cells may initiate and enhance the early development of cardiovascular disease.
Method and Results: We assayed F^sub 2^-isoprostanes, oxidation products of arachidonic acid, by gas chromatography-mass spectrometry in a biracial cohort of 2850 young healthy adult men and women. Coronary artery calcification (CAC), a component of coronary artery atherosclerosis, was detectable in 10% of the cohort and appeared to be in its initial stages (Agatston scores <20 in 47% and <100 in 83% of CAC-positive participants). After adjusting for sex, clinical site, age, and race, the presence of any CAC was 24% more likely among those with high vs ...