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Exfoliation of Helicobacter pylori from Gastric Mucin by Glycopolypeptides from Buttermilk
- Article from:
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Journal of Dairy Science
- Article date:
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January 1, 2005
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Copyright informationCopyright American Dairy Science Association Jan 2005. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT
In the human stomach, Helicobacter pylori, an ulcer pathogenic bacterium, colonizes the gastric mucosal layer primarily. The ability of glycopolypeptides (GPP) prepared from buttermilk to exfoliate H. pylori bound to gastric mucin was investigated. The GPP were prepared from buttermilk by digestion with trypsin, papain, pancreatin, bromelain, or pepsin. Helicobacter pylori ATCC 43504^sup T^ and 43579 adhered more strongly to all of the GPP tested than to whole buttermilk, the soluble fraction of buttermilk, gastric mucin prepared from mouse stomach, or commercial pig gastric mucin. The GPP digested with trypsin, papain, or pancreatin were significantly more adherent. When the GPP ...
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