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Article: Evaluation of Mast Cells in Myeloproliferative Disorders and Myelodysplastic Syndromes

Article from:
Archives of Pathology & Laboratory Medicine
Article date:
February 1, 2005
Author:
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* Context.-Mast cells may be increased as a reactive mastocytosis in various hematologic disorders and malignant neoplasms, as well as in systemic mast cell disease (SMCD). There are no statistical differences in mast cell numbers in reactive mastocytosis and SMCD; however, SMCD usually reveals dyspoietic mast cells and other dyspoietic bone marrow elements. In addition, SMCD is frequently (45%) associated with myeloproliferative disorders (MPDs) (17%) and myelodysplastic syndromes (MDSs) (28%). Thus, it has been suggested that SMCD may represent one aspect of a hematologic disorder that involves multiple bone marrow lineages.

Objective.-To perform a systematic evaluation of MPDs and MDSs ...

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