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Spinal 2-Chloroprocaine: Minimum Effective Dose
- Article from:
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Regional Anesthesia and Pain Medicine
- Article date:
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January 1, 2005
- Author:
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Copyright informationCopyright Churchill Livingstone Inc., Medical Publishers Jan/Feb 2005. Provided by ProQuest LLC. (Hide copyright information)
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Background and Objectives: Recent studies using preservative-free 2-chloroprocaine (2-CP) for spinal anesthesia have shown it to be a reliable short-acting agent in the 30-mg to 60-mg range. Investigations of doses below this range have not been performed.
Methods: To establish the minimum effective dose for spinal anesthesia, this randomized, double-blind, crossover study investigates the characteristics of spinal 2-CP 10 mg and 20 mg in 8 volunteers and compares the results with previous data obtained for 30 to 60 mg in the same human model.
Results: Peak block height, regression to L1, tolerance to tourniquet, and transcutaneous electrical stimulation all increased with increasing doses ...
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