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Genomic imbalances in childhood medulloblastoma by comparative genomic hybridization
- Article from:
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Turkish Journal of Cancer
- Article date:
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October 1, 2003
- Author:
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Copyright informationCopyright Turkish Association for Cancer Research and Control Oct-Dec 2003. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT
We used comparative genomic hybridization (CGH) technique to identify the genetic changes in 12 childhood medulloblastoma samples obtained from archived paraffin-embedded tissues belonging to children (0.7-15 years-old) using double step degenerate oligonucleotide-primed polymerase chain reaction (DOP-PCR). CGH analysis showed that the most common genetic alterations were gains of chromosomes 4p15p16, 7p21p22, 9q22q31, 14q31, 17p12, and Xp11 and non-specific losses. In conclusion, the regions of the chromosomes 9q22q31, 14q31, and 17p12 may harbour the novel site for oncogene(s) and/or tumor suppressor gene(s) playing role in transformation and progression of childhood ...
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