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Article: Histomorphologic Assessment of Formalin Substitute Fixatives for Diagnostic Surgical Pathology

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Archives of Pathology & Laboratory Medicine
Article date:
April 1, 2005
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Context.-In 1987, the Formaldehyde Standard became law in the United States, alerting laboratory workers to the potential carcinogenicity of formaldehyde. As a result, a variety of proprietary fixatives were developed for use in surgical pathology.

Objective.-To assess histomorphology with different formalin substitute fixatives.

Design.-Four experienced board-certified surgical pathologists examined 7 specimens (hepatocellular carcinoma, ovarian sex cord/stromal tumor, myxoid liposarcoma, uterine endometrioid adenocarcinoma, splenic follicular hyperplasia, infiltrating mammary carcinoma, and cecal signet ring carcinoma) fixed with formalin and 5 proprietary fixatives advertised as formalin ...

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