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Quality control in the nucleus

Researchers have discovered the first protein quality control system in the yeast nucleus. They report that the system involves an ubiquitin-protein ligase that specifically targets four distinct mutant nuclear proteins for destruction by the proteasome.1

Protein quality control systems have long been known to exist both in prokaryotes and eukaryotes, but only in compartments where protein synthesis occurs, says coauthor Dan Gottschling of Seattle's Fred Hutchinson Cancer Research Center. "We wanted to find a place where proteins that become old could be recognized and degraded," he says, "and the nucleus is the only compartment in which that could potentially happen."

Their approach was a ...

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