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Article: Extended-Duration Analgesia: Update on Microspheres and Liposomes
- Article from:
- Regional Anesthesia and Pain Medicine
- Article date:
- May 1, 2005
- Author:
CopyrightCopyright Churchill Livingstone Inc., Medical Publishers May/Jun 2005. Provided by ProQuest LLC. (Hide copyright information)
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Local anesthetics delivered peripherally or to the neuraxis constitute an important component of multimodal management of acute postoperative pain and certain chronic pain conditions. Besides providing excellent analgesia at rest and with movement, the opioid-sparing effects of local anesthetics are associated with reduced opioid-related side effects.1 However, in the absence of continuous delivery modalities such as patient-controlled epidural analgesia or continuous perineural catheters, the analgesic benefits of even the longest-acting local anesthetics are limited to <6 hours when placed subcutaneously and to <20 hours for a typical femoral nerve block.2 Attempts to prolong neural ...
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