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Elevated Fibroblast Growth Factor 23 in Women With Malignant Ovarian Tumors

OBJECTIVE: To determine whether fibroblast growth factor 23 (FGF23) concentrations are altered in women with ovarian cancers in which FGF physiology is known to be abnormal.

PATIENTS AND METHODS: Between May 2002 and September 2003 at the Mayo Clinic in Rochester, Minn, plasma or serum FGF23 concentrations were measured in 39 healthy women and in 14 with benign ovarian tumors, 14 with early-stage ovarian cancer, and 13 with advanced-stage ovarian cancer, Immunohis-tochemistry using anti-human FGF23 antibodies was performed on tissue from benign masses and advanced-stage tumors.

RESULTS: Serum or plasma FGF23 concentrations were significantly higher in women with advanced-stage ovarian ...

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