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Fast and Slow Skeletal Troponin I in Serum from Patients with Various Skeletal Muscle Disorders: A Pilot Study
- Article from:
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Clinical Chemistry
- Article date:
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June 1, 2005
- Author:
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Copyright informationCopyright American Association for Clinical Chemistry Jun 2005. Provided by ProQuest LLC. (Hide copyright information)
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Background: Detection of skeletal muscle injury is hampered by a lack of commercially available assays for serum markers specific for skeletal muscle; serum concentrations of skeletal troponin I (sTnI) could meet this need. Moreover, because sTnI exists in 2 isoforms, slow (ssTnI) and fast (fsTnI), corresponding to slow- and fast-twitch muscles, respectively, it could provide insight into differential injury/recovery of specific fiber types. The purpose of this study was to investigate whether the 2 isoforms of sTnI and their modified forms are present in the blood of patients with various skeletal muscle disorders.
Methods: Serial serum samples were obtained from 25 patients with various ...