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Article: Protein Synthesis and Translation Initiation Factor Activation in Neonatal Pigs Fed Increasing Levels of Dietary Protein1,2
- Article from:
- The Journal of Nutrition
- Article date:
- June 1, 2005
- Author:
CopyrightCopyright American Institute of Nutrition Jun 2005. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT
Limited data suggest that the growth of low-birth-weight infants is enhanced by feeding a high-protein diet; however, the mechanisms involved in the effect have not been delineated. To identify these mechanisms, 34 pigs were fed from 2 to 7 d of age [60 g dry matter/(kg body weight . d)] isocaloric milk diets that contained levels of dietary protein that were marginal, adequate, and in excess of the piglets protein requirement (21, 33, and 45% of dry matter, respectively). Dietary protein replaced lactose and fat on an isocaloric basis. Fractional protein synthesis rates, various biomarkers of translational regulation, and plasma glucose and insulin levels were measured in ...