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Preferential placental transfer of Helicobacter pylori specific IgG

Objective: To evaluate the placental transfer of Helicobacter pylori-specific IgG in Iranian mothers.

Method: The antibodies were measured in sera of 156 mother/newborn pairs using a commercially available indirect Enzyme Linked Immunosorbent Assay (ELISA). The study population was among healthy pregnant women who attended to the Zeinabieh hospital of Shiraz University of Medical Sciences in 1999.

Results: In total 74.7% of mothers were seropositive and more than 82% of seropositive mothers transferred Helicobacter pylori-specific IgG antibodies to their fetuses. The mean maternal Helicobacter pylori-specific IgG was significantly higher than that of the newborns (104.01 vs. 68.30 IU/ml, p ...

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