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The use of percutaneous autologous bone marrow transplantation in nonunion and avascular necrosis of bone

Bone marrow and orthopaedic surgery

During the development of normal bone in the young child, osteoblasts and then haematopoietic stem cells progressively colonise the cartilaginous matrix, resulting in its ossification to bone matrix.1 It is at this time that red bone marrow appears in the skeleton, starting distally in the foot and hand at around one year of age. In normal children, the marrow in all bone cavities and the spongiosa at the epiphysis is red, because the amount of medullary space in young children is limited due to an abundance of cartilage and the thickness of spongy bone, while the haematopoietic requirements are high due to the growth-related expansion of the blood ...

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