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Tissue Distribution of Quercetin in Rats and Pigs1
- Article from:
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The Journal of Nutrition
- Article date:
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July 1, 2005
- Author:
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Copyright informationCopyright American Institute of Nutrition Jul 2005. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT
Quercetin is a dietary polyphenolic compound with potentially beneficial effects on health. Claims that quercetin has biological effects are based mainly on in vitro studies with quercetin aglycone. However, quercetin is rapidly metabolized, and we have little knowledge of its availability to tissues. To assess the long-term tissue distribution of quercetin, 2 groups of rats were given a 0.1 or 1% quercetin diet [~50 or 500 mg/kg body weight (wt)] for 11 wk. In addition, a 3-d study was done with pigs fed a diet containing 500 mg quercetin/kg body wt. Tissue concentrations of quercetin and quercetin metabolites were analyzed with an optimized extraction method. Quercetin and ...
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