Articles > Journals > Medical journals > The Journal of Nuclear Medicine articles > August 2005

Article: Treatment with ^sup 177^Lu-DOTATOC of Patients with Relapse of Neuroendocrine Tumors After Treatment with ^sup 90^Y-DOTATOC

Article from:
The Journal of Nuclear Medicine
Article date:
August 1, 2005
Author:
Copyright

Therapy with [^sup 90^Y-DOTA^sup 0^, Tyr^sup 3^]-octreotide (DOTATOC, where DOTA = tetraazacyclododecane tetraacetic acid and TOC = D-Phe-c(Cys-Tyr-D-Trp-Lys-Thr-Cys)-Thr(ol)) is established for the treatment of metastatic neuroendocrine tumors. Nevertheless, many patients experience disease relapse, and further treatment may cause renal failure. Trials with ^sup 177^Lu-labeled somatostatin analogs showed less nephrotoxicity. We initiated a prospective study with ^sup 177^Lu-DOTATOC in patients with relapsed neuroendocrine tumors after ^sup 90^Y-DOTATOC treatment. Methods: Twenty-seven patients, pretreated with ^sup 90^Y-DOTA-TOC, were included. The mean time between the last treatment with ...

Read all of this article with a FREE trial

Related newspaper, magazine, and journal articles:

Article: Potential Increased Tumor-Dose Delivery with Combined ^sup ...
The Journal of Nuclear Medicine;  April 1, 2006 ;     700+ words ... ... either ^sup 131^I-MIBG or ^sup 90^Y-DOTATOC. The results obtained from ... combining both ^sup 90^Y-DOTATOC and ^sup 131^I-MIBG. As shown in ... therapy with ^sup 90^Y-DOTATOC and ^sup 131^I-MIBG are explored ...

Article: Patient-Specific Dosimetry in Predicting Renal Toxicity with ...
The Journal of Nuclear Medicine;  January 1, 2005 ;     700+ words ... ... D-Phe^sup 1^-Tyr^sup 3^-octreotide (DOTATOC). Pretherapeutic assessment ... dose during therapy with ^sup 90^Y-DOTATOC. In particular, we investigated ... underwent treatment with ^sup 90^Y-DOTATOC (8.1-22.9 GBq) after ...

Article: Tumor Response and Clinical Benefit in Neuroendocrine Tumors ...
The Journal of Nuclear Medicine;  May 1, 2002 ;     700+ words ... ... acetyl-D-Phe-Tyr^sup 3^-octreotide (DOTATOC). In addition, we investigated ... the clinical benefit of ^sup 90^Y-DOTATOC regarding the malignant carcinoid ... 7.4 GBq/m^sup 2^ ^sup 90^Y-DOTATOC, administered at intervals ...

Article: ^sup 90^Y-DOTATOC and Merkel Cell Carcinoma
The Journal of Nuclear Medicine;  July 1, 2004 ;     407 words ... ... PheTyr-roctreotide (^sup 90^Y-DOTATOC) in an 83-year-old woman ... was treated 4 times with ^sup 90^Y-DOTATOC, and 2 complete remissions ... toxicities were noted with the ^sup 90^Y-DOTATOC. The authors concluded that ...

Article: Dosimetric Model for Locoregional Treatments of Brain Tumors with ...
The Journal of Nuclear Medicine;  January 1, 2006 ;     700+ words ... ... sup 3^]octreotide (^sup 90^Y-DOTATOC). Methods: An anthropomorphic ... treatments, 0.4-1.1 GBq of ^sup 90^Y-DOTATOC were injected into the SRC ... results, LR treatment with ^sup 90^Y-DOTATOC can safely deliver very high ...

Article: YTTRIUM-90-DOTATOC THERAPY IN PATIENTS WITH NEUROENDOCRINE ...
Journal of Nuclear Medicine Technology;  June 1, 2004 ;     590 words ... ... therapy (PRRT) with [Y-90]DOTATOC has evolved as a promising therapy ... a total of 7,4 GBq [Y-90]DOTATOC /m^sup 2^ body surface area, with the ... Approx. 100 MBq [In-111]DOTATOC were co-injected with [Y-90 ...

Article: Y-90-DOTATOC radionuclide therapy with amino acids reduced ...
Clinical Trials Week;  April 14, 2003 ;     636 words ... ... determine the maximum tolerated dose of Y-90 DOTATOC per cycle administered in association ... 8 groups received 2 cycles of Y-90-DOTATOC, with activity increased by 0.37 GBq ... adverse reactions occurred after Y-90-DOTATOC injection up to 5.55 GBq/cycle. Grade ...

Article: Long-Term Follow-Up of Renal Function After Peptide Receptor ...
The Journal of Nuclear Medicine;  January 1, 2005 ;     700+ words ... ... octreotide (^sup 90^Y-DOTATOC) or ^sup 177^Lu-DOTA^sup 0^,Tyr ... after PRRT with ^sup 90^Y-DOTATOC and ^sup 177^Lu-DOTA^sup 0^,Tyr ... tolerated doses of ^sup 90^Y-DOTATOC (^sup 90^Y-SMT487, ^sup 90 ...

 
 
Newsweek Harper's Magazine The Washington Post Chicago Tribune Crain's Chicago Business PRNewswire Pediatric News The Nation Advertising Age The Economist (US) A FREE trial gives you access to over 80 million articles! Access over 6,500 publications with a FREE trial!

Find articles, research, and archives