Articles > Journals > Medical journals > British Journal of Biomedical Science articles > April 2005

Article: Antibody response to Toxoplasma gondii in saliva samples from human immunodeficiency virus-infected patients

Article from:
British Journal of Biomedical Science
Article date:
April 1, 2005
Author:
Copyright

ABSTRACT

Toxoplasma gondii is an important opportunistic infection among human immunodeficiency virus (HIV)-infected patients as it causes fatal encephalitis. In the present study, antibody response to T. gondii is assessed in saliva samples from 100 HIV-seropositive patients and 25 HIV-negative healthy controls by indirect enzymelinked immunosorbent assay (ELISA). Sensitivity and specificity for detection of IgG and IgM in saliva is calculated using a positive antibody response in serum samples (from an earlier study) as the gold standard. IgG and IgM antibodies were found in 20% and 25% patients, respectively. One control subject showed the presence of IgM antibody. Sensitivity for IgG ...

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