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Article: Vitamin D Deficiency Enhances the Growth of MC-26 Colon Cancer Xenografts in Balb/c Mice1,2
- Article from:
- The Journal of Nutrition
- Article date:
- October 1, 2005
- Author:
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Copyright informationCopyright American Institute of Nutrition Oct 2005. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT
Vitamin D deficiency has been associated with increased risk of colon cancer in epidemiologic and prospective clinical studies. In vitro and in vivo studies demonstrated that 1,25-dihydroxycholecalciferol [1,25(OH)^sub 2^D^sub 3^] and its analogs inhibit colon cancer cell proliferation. Few studies have evaluated the effect of vitamin D deficiency on the development and growth of colon cancer. To assess the antiproliferative effects of 25-hydroxyvitamin D [25(OH)D] and 1,25(OH)^sub 2^D^sub 3^ in vitro, we cultured MC-26 (a colon cancer cell line) in the presence of 25(OH)D^sub 3^ and 1,25(OH)^sub 2^D^sub 3^ and performed [^sup 3^H]thymidine incorporation. The proliferation of MC-26 ...
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