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Effects of a High-Fiber Diet on Hepatocyte Apoptosis and Liver Regeneration After Partial Hepatectomy in Rats With Fatty Liver
- Article from:
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JPEN, Journal of Parenteral and Enteral Nutrition
- Article date:
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November 1, 2005
- Author:
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Copyright informationCopyright American Society for Parenteral and Enteral Nutrition Nov/Dec 2005. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT. Background: The morbidity and mortality that accompany fatty liver may occur as a result of increased apoptosis of hepatocytes and decreased liver regeneration. We determined the effects of a high-fiber diet on hepatocyte apoptosis and liver regeneration after partial hepatectomy in rats with fatty liver. Methods: Fatty liver was induced in male Wistar rats weighing around 200 g through feeding of a high-fat diet for 4 weeks. The rats were then randomly assigned to 3 groups that received a high-fat diet, a normal diet, or a high-fiber diet for another 4 weeks. Partial hepatectomy (around 70%) was performed, and rats were killed 6, 24, 48, or 72 hours after hepatectomy. We then ...
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