Article: Biotin defiency decreases ornithine transcarbamylase activity and mRNA in rat liver

Article: Marginal Maternal Biotin Deficiency in CD-1 Mice Reduces Fetal Mass of Biotin-dependent Carboxylases1,2
The Journal of Nutrition;  May 1, 2005 ;     700+ words ...ABSTRACT Marginal maternal biotin deficiency reduces hepatic activity of biotin-depende...mice were fed a diet that induced biotin deficiency or a biotin-sufficient diet. On gestational...was determined by real-time RT-PCR. Biotin deficiency significantly reduced the abundance...

Article: Certain immune markers are not good indicators of mild to moderate biotin deficiency in rats
The Journal of Nutrition;  December 1, 2001 ;     700+ words ......Indicators of Mild to Moderate Biotin Deficiency in Rats1 ABSTRACT To assess the effects of marginal biotin deficiency on immune function and thereby...from sufficiency to moderate biotin deficiency. As immune function indicators...

Article: UAMS Leads Search for Answers on Cleft Palate, Other Biotin-related Birth Defects.
PR Newswire;  January 6, 2003 ;     700+ words ......urine test for mild, or marginal, biotin deficiency -- a critical step in the painstaking...of confirming and explaining why biotin deficiency causes birth defects. Mock has been...this be?' I knew of 1940s studies of biotin deficiency and I'd seen inborn errors of metabolism...

Article: Biotin Deficiency Blocks Thymocyte Maturation, Accelerates Thymus Involution, and Decreases Nose-Rump Length in Mice1
The Journal of Nutrition;  August 1, 2004 ;     700+ words ...ABSTRACT Biotin deficiency in experimental animals causes...reported previously that chronic biotin deficiency in mice decreases body weight...characterize the effects of biotin deficiency, we studied in detail the maturation...

Article: 3-Hydroxypropionic Acid and Methylcitric Acid Are Not Reliable Indicators of Marginal Biotin Deficiency in Humans1
The Journal of Nutrition;  February 1, 2004 ;     700+ words ......subjects, respectively, marginal biotin deficiency was induced experimentally by an...sensitive an indicator of marginal biotin deficiency as 3-hydroxyisovaleric acid, which...2004. KEY WORDS: * organic acid * biotin deficiency * human * 3-hydroxypropionic acid...

Article: Marginal biotin deficiency is teratogenic in ICR mice1,2
The Journal of Nutrition;  August 1, 2003 ;     700+ words ......ABSTRACT The incidence of marginal biotin deficiency in normal human gestation is approximately...one in three. In ICR mice, maternal biotin deficiency results in cleft palate, micrognathia...relationships among the severity of maternal biotin deficiency, fetal biotin status and ...

Article: Biotin Deficiency Reduces Expression of SLC19A3, a Potential Biotin Transporter, in Leukocytes from Human Blood1,2
The Journal of Nutrition;  January 1, 2005 ;     700+ words ......subjects before and after inducing marginal biotin deficiency. Biotin deficiency was induced experimentally by feeding an...relatively sensitive indicator of marginal biotin deficiency. J. Nutr. 135: 42-47, 2005. KEY WORDS...

Article: Introduction to "Advances in Understanding of the Biological Role of Biotin at the Clinical, Biochemical, and Molecular Level"1,2
The Journal of Nutrition;  January 1, 2009 ;     700+ words ......Mock (1) reviewed evidence that biotin deficiency develops during normal human gestation and that biotin deficiency is teratogenic in some species...and Dudas (2) suggesting that biotin deficiency might be teratogenic in humans...

Article: Marginal Biotin Deficiency is Common in Normal Human Pregnancy and Is Highly Teratogenic in Mice1-3
The Journal of Nutrition;  January 1, 2009 ;     700+ words ...Abstract In studies of marginal biotin deficiency induced experimentally in adults...biotin deficient. In mice, degrees of biotin deficiency that are metabolically similar to...Moreover, in mice, a marginal degree of biotin deficiency in the dam causes a much more severe...

Article: Lymphocyte propionyl-CoA carboxylase is an early and sensitive indicator of biotin deficiency in rats, but urinary excretion of 3-hydroxypropionic acid is not
The Journal of Nutrition;  July 1, 2002 ;     700+ words ......Early and Sensitive Indicator of Biotin Deficiency in Rats, but Urinary Excretion of...have provided evidence that marginal biotin deficiency is more common than previously thought...carboxylase. Marginal-to-moderate biotin deficiency was induced experimentally by an...

Article: Measurement of 3-Hydroxyisovaleric Acid in Urine of Biotin-Deficient Infants and Mice by HPLC1
The Journal of Nutrition;  March 1, 2005 ;     700+ words ......by this method, as an indicator of biotin deficiency. Therefore, the HPLC method for 3-H...3-hydroxyisovaleric acid * HPLC * biotin deficiency * methyicrotonyl CoA carboxylase...individuals. Conditions that cause biotin deficiency include the following: long-term...

Article: Biotin Deficiency Affects the Proliferation of Human Embryonic Palatal Mesenchymal Cells in Culture1,2
The Journal of Nutrition;  April 1, 2008 ;     700+ words ......pregnancy in women may cause mild biotin deficiency without any clinical signs. However, the teratogenicity of biotin deficiency in humans has not been well...have shown that maternal biotin deficiency induces many kinds of malformations...

Article: Biotin status: Which are valid indicators and how do we know?
The Journal of Nutrition;  February 1, 1999 ;     700+ words ......early and sensitive indicator of biotin deficiency, but decreased serum concentration...early and sensitive indicator of biotin deficiency. When these indicators were assessed...pregnancy. Thus, each indicator detected biotin deficiency late in pregnancy, but assessment...

Article: Low maternal biotin levels cause fetal malformations in study animals.
Health & Medicine Week;  September 29, 2003 ;     464 words ......animals. The incidence of marginal biotin deficiency in normal human gestation is approximately...one in three. In ICR mice, maternal biotin deficiency results in cleft palate, micrognathia...relationships among the severity of maternal biotin deficiency, fetal biotin status and ...