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Performance of the Revised Bethesda Guidelines for Identification of Colorectal Carcinomas With a High Level of Microsatellite Instability
- Article from:
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Archives of Pathology & Laboratory Medicine
- Article date:
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November 1, 2005
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Copyright informationCopyright College of American Pathologists Nov 2005. Provided by ProQuest LLC. (Hide copyright information)
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Context.-Criteria for microsatellite instability (MSI) testing to rule out hereditary nonpolyposis colorectal cancer were recently revised and include parameters such as age and specific histologie features that can be identified by the pathologist, triggering reflex MSI testing.
Objective.-To review the performance of the revised Bethesda guidelines to identify MSI-positive colorectal cancers.
Design.-Seventy-five patients with colorectal cancer were included; 68 patients younger than 50 years and 7 patients between 50 and 60 years were selected based on histopathologic criteria. Microsatellite instability testing with the National Cancer Institute-recommended panel and ...
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