Article: Effects of vitamin K on bone mass and bone metabolism

Vitamin K is involved in the synthesis of a number of well-defined proteins, the vitamin K-dependent step being the addition of an extra carboxyl group at the gamma-position of glutamate residues (Vermeer 1990). The product formed is an unusual amino acid called gamma-carboxyglutamate (Gla).(3) There are two physiological processes in which Gla-proteins are known to play a role: blood coagulation and bone metabolism (Hauschka et al. 1989, Shearer 1995). Those participating in blood coagulation are of hepatic origin, whereas the bone Gla-proteins are synthesized by the bone-forming cells (osteoblasts). Recent publications indicate that Gla-proteins may also be involved in the regulation of ...

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