Article: Developmental expression and vitamin D regulation of calbindin-D28K in chick embryonic yolk sac endoderm

A number of studies have clearly demonstrated the importance and requirement of vitamin D in chick embryonic development. These investigations ranged from the classical studies that demonstrated a sharp decrease in hatchability in embryos from vitamin D-deficient hens (Bethke et al. 1936, Branion and Smith 1932) to more recent studies in which vitamin D-deficient embryos were generated from the feeding of laying hens with 1,25-dihydroxy vitamin D sub 3 (calcitriol) substituting for vitamin D (Hart and DeLuca 1985, Henry and Norman 1978, Sunde et al. 1978, Narbaitz and Tsang 1989, Narbaitz et al. 1987). Such vitamin D-deficient chick embryos consistently showed very low hatchability and ...

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