Article: Reducing pain with genetic amniocentesis-A randomized trial of subfreezing versus room temperature needles

Abstract

Objective. To determine whether pain associated with second trimester genetic amniocentesis is decreased by using subfreezing rather than room temperature needles.

Methods. Subjects were randomized to a - 14°C or room temperature (20-22°C) 22-gauge spinal needle. Patients, blinded to allocation, recorded anticipated and actual pain before and after the procedure, respectively, using a 0-10 visual analog scale with 0 = no pain and 10 = excruciating pain.

Results. Thirty-three subjects were randomized to room temperature and 29 subjects to subfreezing needles. Anticipated pain was similar in room temperature, 5.1 ± 1.7, and subfreezing groups, 4.9 ± 2.0, respectively (p = 0.6). ...

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