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Article: The Vitamin D^sub 3^ Pathway in Human Skin and its Role for Regulation of Biological Processes

Article from:
Photochemistry and Photobiology
Article date:
November 1, 2005
Author:
Copyright

UV Radiation, Vitamin D and Human Health: An Unfolding Controversy

ABSTRACT

The skin is the only tissue yet known in which the complete ultraviolet-B (UV-B)-induced pathway from 7-dehydrocholesterol to hormonally active calcitriol (1α,25-dihydroxyvitamin D^sub 3^) occurs under physiological conditions. Epidermal synthesis of calcitriol could be of fundamental relevance because calcitriol regulates important cellular functions in keratinocytes and immunocompetent cells. Because of their antiproliferative and prodifferentiating effects, calcitriol and other vitamin D analogs are highly efficient in the treatment of psoriasis vulgaris. The known antipsoriatic effect of UV-B light could, ...

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