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Is Delayed Childbearing Changing Gene Frequencies in Western Populations?
- Article from:
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Human Biology
- Article date:
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August 1, 2005
- Author:
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Copyright informationCopyright Wayne State University Press Aug 2005. Provided by ProQuest LLC. (Hide copyright information)
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Abstract
Experimental data and clinical observations suggest that delaying childbearing influences the biology of the mother-fetus relationship, with a negative effect on fetal development and predisposition to severe diseases such as type 1 diabetes. We reason that advanced maternal age may influence intrauterine selection, favoring genotypes that are more adapted to the intrauterine environment of less young women. In the present study we have investigated the relationship of maternal age to HP genotype and PGM1-Rh area (chromosome 1) that have been previously found to be associated with fertility and developmental parameters. HP phenotype was determined in 679 consecutive puerperae from ...
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