|
|
Article: Colonic Fermentation May Play a Role in Lactose Intolerance in Humans1
- Article from:
- The Journal of Nutrition
- Article date:
- January 1, 2006
- Author:
CopyrightCopyright American Institute of Nutrition Jan 2006. Provided by ProQuest LLC. (Hide copyright information)
|
ABSTRACT
The results of our previous study suggested that in addition to the small intestinal lactase activity and transit time, colonic processing of lactose may play a role in lactose intolerance. We investigated whether colonic fermentation of lactose is correlated with lactose intolerance. After 28 Chinese subjects had undergone 1 glucose (placebo) and 2 lactose challenges, consistent lactose tolerant (n = 7) and intolerant (n = 5) subjects with no complaints after glucose administration were classified on the basis of the 6-h symptom scores. Before the challenges, fecal samples were collected for in vitro incubation with lactose. The incubation was carried out in a static system under ...