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Article: Chlormadinone acetate (CMA) in oral contraception - a new opportunity
- Article from:
- European Journal of Contraception & Reproductive Health Care
- Article date:
- January 1, 2005
- Author:
CopyrightCopyright CRC Press 2005. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT
Chlormadinone acetate (CMA) is a derivative of naturally secreted progesterone that shows high affinity and activity at the progesterone receptor. It has an anti-estrogenic effect and, in contrast to natural progesterone, shows moderate anti-androgenic properties. CMA acts by blocking androgen receptors in target organs and by reducing the activity of skin 5α-reductase. It suppresses gonadotropin secretion and thereby reduces ovarian and adrenal androgen production. CMA shows high contraceptive efficacy by inhibiting ovulation due to its ability to suppress or disrupt endogenous gonadotropin secretion and, by this, inhibits follicular growth and maturation. In addition, it ...