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Article: ^sup 99m^Tc-Labeled mAb Detection of Ganglioside Expression in Breast Cancer
- Article from:
- The Journal of Nuclear Medicine
- Article date:
- February 1, 2006
- Author:
CopyrightCopyright Society of Nuclear Medicine Feb 2006. Provided by ProQuest LLC. (Hide copyright information)
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In an article e-published on December 2 ahead of print in Breast Cancer Research and Treatment, Oliva et al. from the National Institute of Oncology and Radiobiology (Havana. Cuba) described the use of ^sup 99m^Tc-labeled monoclonal antibody scintigraphy for in vivo detection of GM3(NeuGc) gangliosides in human breast tumors. Gangliosides are considered promising targets for cancer immunotherapy. and the GM3(NeuGc) ganglioside of is special interest because of previous research suggesting its low expression in normal tissues and overexpression in human breast tumor. The authors applied a radioimmunoscintigraphic technique with 3 different doses of technetiumlabeled 14F7, ...
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